Senior Director, Clinical Pharmacology

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions.   Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work ® in 2026. Description of Role Centessa is seeking an experienced Senior Director, Clinical Pharmacology (translational) to provide scientific and strategic leadership for translational clinical pharmacology across a diverse pipeline spanning early development through late‑stage and registrational programs. Reporting to the Executive Director, Clinical Pharmacology, this position is accountable for developing and executing clinical pharmacology strategies that address the unique challenges of neuroscience drug development, including CNS exposure, dose optimization, and translational relevance. The Senior Director partners closely with cross‑functional teams, and cross-program teams to achieve broader translational understanding of our assets, and application of that knowledge to development programs. Additionally, they will represent clinical pharmacology in regulatory interactions to enable efficient, data‑driven advancement of therapies across our neuroscience portfolio.  Key Responsibilities Lead strategy for collection and interpretation of information across in vitro, in vivo, literature of competitive sources, and clinical data to develop a translational knowledge base to Centessa assets   Drive dose selection and optimization by integrating PK, PD, safety, efficacy, and CNS‑specific biomarkers   Lead model‑informed drug development, including population PK, PK/PD, and exposure–response analyses relevant to CNS targets and clinical safety  Assess and guide strategies for CNS exposure, brain penetration, target engagement, and translational biomarkers   Lead clinical pharmacology strategy for CNS and neuroscience programs from first‑in‑human through registrational and post‑marketing stages   Design, execute, and interpret clinical pharmacology studies, including FIH, multiple‑ascending dose, DDI, biopharmaceutics, and patient studies   Serve as the clinical pharmacology lead on program teams, clinical sub‑teams, and trial working groups   Author and oversee clinical pharmacology sections of regulatory documents (e.g., INDs, CTAs, IBs, NDAs)   Represent clinical pharmacology in interactions with FDA and other global health authorities, supporting dose justification and labeling discussions   Partner closely with DMPK, Translational Sciences, Clinical Development, Biomarkers, Biostatistics, CMC, and Regulatory Affairs   Oversee CROs and external vendors conducting clinical pharmacology and modeling activities   Ensure timely communication and clear interpretation of clinical pharmacology results to internal stakeholders   Contribute to portfolio strategy, program prioritization, risk mitigation, and long‑range clinical development planning for CNS assets   Serve as a subject‑matter expert on clinical pharmacology   Mentor and develop clinical pharmacology talent as the pipeline and organization grow   Ensure high‑quality, submission‑ready documentation aligned with global regulatory standards  Qualifications PhD, PharmD, or MD in Clinical Pharmacology, Pharmacokinetics, Pharmaceutical Sciences, or a related discipline   8–12+ years of experience in clinical pharmacology within biopharma, with demonstrated impact in translational science in drug development   Strong expertise in PK, PD, PK/PD integration, exposure–response analyses, and drug–drug interaction assessment   Extensive experience developing and executing clinical pharmacology strategies for early‑ through late‑stage programs, including registrational support   Demonstrated experience applying quantitative clinical pharmacology and translational approaches (e.g., population PK, mechanistic PK/PD modeling) to inform CNS dose selection and optimization   Proficiency with clinical pharmacology tools and platforms such as NONMEM, R, Phoenix WinNonlin, SimCyp, or equivalent   Experience authoring and delivering clinical pharmacology components of regulatory submissions (e.g., INDs, CTAs, NDAs) and interacting with global health authorities   Strong understanding of translational PK, CNS exposure considerations, and biomarker integration in neuroscience drug development   Excellent communication, collaboration, and leadership skills with the ability to operate effectively in a fast‑paced, matrixed environment  Compensation The annual base salary range for this position is $195,000 to $275,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, job knowledge and location. In addition to base pay, this role is eligible for a discretionary annual bonus. The Company  also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program. Work Location The Senior Director, Clinical Pharmacology role is remote based, with occasional travel. POSITION:  Full-Time, Exempt EEOC Statement: Centessa Pharmaceuticals, a wholly owned subdisary of Eli Lilly and Company believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hirin