Vertex Spring Co-Op 2027, Long Read Sequencing

Job Description Kickstart Your Career at Vertex!    Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab.  Why Vertex?   Real Projects:  You’ll work on assignments that make a real impact, not just busy work.  Mentorship & Networking:  Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your longer-term career.  Flexible & Supportive:  We offer flexible work options with Flex @ Vertex and prioritize your wellbeing.  Inclusive Culture:  Collaboration and inclusion are embedded in everything we do.  Career Launchpad:  Build skills, explore career paths, and get guidance for your future career.  Your Impact  The Vertex Long Read Sequencing Co-Op is a 6-month experiential training program for students currently working towards an advanced degree in Biological Sciences, or other related fields. If you are passionate, collaborative, and growth-minded, a co-op at Vertex will help you gain meaningful experience in our BSMO CGT AD functional areas and serve as a launchpad for your career.   The application deadline for this co-op is November 15th. Please note that Vertex reviews applications on a rolling basis and reserves the right to close this job posting prior to the listed deadline. Applicants can expect to receive an update about their application before or shortly after the application deadline.   Ready to apply? Submit your application and let’s turn possibilities into reality!     What you will be doing:    The long sequencing project will cover various applications listed below: RNA Sequencing for modification (m6a, m5c, pseudouridine, etc.) and isoform analysis to characterize stem cells and stem cell derived pancreatic islets. Conduct plasmid integration analysis for development and assessment of monoclonal antibody-producing cell lines, using targeted or whole genome sequencing. Direct RNA or cDNA sequencing to verify monoclonal antibody heavy- and light-chain sequences and support variant calling. Evaluate mRNA integrity and polyA tail characterization using direct RNA sequencing. Required Skills: Nucleic acid extraction, cDNA preparation and sequencing library preparation Ability to design and analyze experiments for developing analytical assay Experience with Oxford Nanopore systems Proficiency with R or Python, Linux system and high process computing system Familiarity with bioinformatics tools such as minimap2 and samtools Data analysis tools such as DESEQ2 and Gene Set Enrichment Analysis Key Deliverables at Project Completion : Establish workflows/assay to support applications of long read sequencing Execution of the experiments and analyzing the dataset with statistical approach Key Learnings Expected: Knowledge pertaining to developing an assay and bringing it through feasibility assessment such as accuracy and precision. Deeper understanding into principles of stem cell and pancreatic islets biology Presentation of large dataset and experimental findings. Qualifications: Master's / PhD Majors: Systems Biology, Computational Biology, Developmental Biology, Stem Cell Biology, Biochemistry, Biological Engineering, etc. Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships/co-ops or entry level roles within this part of the organization.  You must be enrolled in an advanced degree program if graduating before June 2027  You must be available to work full-time, 40 hours per week from January – June 2027  Program Details:    Full-time, paid co-op $35.00 – 50.00 USD/hour  Program Dates: January – July 2027  Application Deadline: November 15th, 2026 At Vertex, we believe that when you feel your best, you can perform at your best. That’s why our US benefits and global well-being resources are designed to support you. • Free 24/7 onsite gym access and free access to group exercise classes  • Subsidized commuter benefits- transit and parking  • Provided meals—free breakfast daily!  • Career development opportunities and events, including C Suite engagement  • Social events—both intern-only and company-wide  • Location-specific perks and extras!  • Recognition of National Intern Day   Our Ways of Working    Flex Designation:  On-Site - Boston Flex Eligibility Status:  On-Site: work five days per week on-site with ad hoc flexibility.  Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.   This job posting is for a temporary role with a third-party agency partner that provides services to Vertex.  The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer.   At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time