Sr. Principal Technical Program Manager, INT Digital

The Role Moderna is seeking a Senior Principal Technical Program Manager to lead the planning and delivery of the digital ecosystem supporting Individualized Neoantigen Therapy (INT). The INT Digital portfolio enables individualized therapies to move from patient order through manufacturing and delivery in a timely, controlled, reliable, and cost-efficient manner, helping maximize access for our patients. The ecosystem spans the products and capabilities that support orchestration, scheduling, enterprise integrations, manufacturing, and quality across Moderna and Merck. This role is accountable for translating business and technology strategy into an executable roadmap across products, engineering teams, offshore delivery teams, SaaS providers, system integrators, and strategic partners. You will drive consistent and predictable delivery by creating the clarity and accountability required to execute the portfolio end to end. You will use delivery telemetry to forecast outcomes, drive cross-company commitments, manage investment and vendors, establish effective governance, and apply sufficient technical depth to challenge assumptions and influence architecture and design decisions. Success requires dynamic range, urgency, and a relentless focus on enabling the greatest possible impact for patients through timely, controlled, reliable, and cost-efficient delivery. Here’s What You’ll Do Lead the planning and delivery of the INT Digital portfolio, translating business and technology strategy into a clear roadmap, executable plans, milestones, dependencies, and measurable outcomes across mINT products and offshore delivery teams. Orchestrate joint delivery with Merck, aligning cross-company priorities, commitments, dependencies, decisions, and timelines so INT capabilities come together end to end in a consistent and coherent way. Supply Product and Engineering leaders with the delivery insights, metrics, and dependency visibility needed to make informed decisions, pivot when the data demands it, and create a high-performing delivery model with shared accountability for outcomes. Establish and run governance mechanisms that create clear commitments, ownership, and decision paths; hold teams and leaders accountable for delivery, decisions, and corrective actions; and remove organizational viscosity that slows execution. Use Scrum and engineering delivery telemetry to accurately forecast delivery, assess delivery confidence, and identify emerging bottlenecks and hot spots before they become material issues. Translate delivery signals, risks, and constraints into corrective actions for teams and clear options, tradeoffs, and recommendations for senior leadership, enabling timely decisions and action with urgency. Apply technical depth and curiosity across the INT ecosystem to critically evaluate and influence architecture and design decisions, question assumptions, surface technical risks, and drive clarity across integrations, system boundaries, data flows, scalability, resilience, and operability. Own portfolio-level financial and resource planning, including labor forecasts, actuals, resource assumptions, spend, and investment tradeoffs, making owner-minded decisions that keep technology investment aligned with priorities, expected outcomes, and the cost-efficient delivery of INT. Lead SaaS providers, vendors, and system integrators against clear expectations for scope, cost, quality, milestones, and outcomes, using performance data to identify gaps early and relentlessly drive corrective action when commitments are at risk. Drive integrated readiness for major INT milestones, bringing together digital delivery, technical readiness, manufacturing, quality, regulatory, and operational dependencies into a single view of readiness, risk, and actions required. Here’s What You’ll Need (Basic Qualifications): Bachelor’s degree or equivalent professional experience in technical program management, computer science, engineering, life sciences, or a related discipline. 9+ years of experience in technical program management or related roles, with demonstrated ownership of complex technology programs spanning multiple teams and functions. Proven experience leading complex, cross-functional programs with significant business impact across multiple products, platforms, or technical workstreams. Demonstrated ability to turn ambiguous business and technology objectives into clear roadmaps, plans, milestones, dependencies, ownership, and measurable outcomes. Strong technical judgment and the ability to engage credibly with engineering and architecture teams on software design, integrations, APIs, data flows, non-functional requirements, and operational considerations. Experience using Scrum, engineering metrics, and delivery telemetry to assess program health, forecast delivery, identify emerging risks, and drive data-informed decisions. Experience driving delivery across organizational boundaries, including external partners, vendors, system integrators, and geographically distributed teams. Experience managing portfolio financials, including labor planning, forecasts, actuals, vendor spend, and investment tradeoffs. Strong executive communication skills with the ability to synthesize complex delivery and technical information into clear insights, recommendations, options, and decisions. Experience operating in pharmaceutical, biotechnology, manufacturing, medical device, or another highly regulated and operationally complex environment. Working knowledge of GxP, Computer System Validation, data integrity, cybersecurity, and regulatory expectations for digital systems supporting regulated operations. Here’s What You’ll Bring to the Table (Preferred Qualifications): You take ownership for outcomes, not simply the plan. You identify where commitments are at risk, confront difficult issues directly, and relentlessly drive teams toward resolution. You ha