Senior Scientist Genomic Medicine BioAnalytics Characterization

Job Title: Senior Scientist Genomic Medicine BioAnalytics Characterization Location: Waltham, MA About the Job:   We are seeking a motivated Senior Scientist to join our BioAnalytics Characterization group in the Genomic Medicine Unit within Sanofi. Candidates with no previous experience in the field of genomic medicine are still encouraged to apply – we are looking primarily for someone with strong mass spectrometry characterization experience and are committed to bridging any knowledge gaps through dedicated onboarding and training. This role offers a unique opportunity to build expertise in the rapidly growing field of genomic medicine, including viral gene therapies and lipid nanoparticles. The future of medicine is being shaped today at Sanofi — apply now and position yourself at the forefront of the next generation of transformative therapeutics.  The Genomic Medicine Unit at Sanofi is dedicated to the establishment of best-in-class platforms to support development of life-changing advanced gene therapy products. The BioAnalytics Characterization group uses advanced analytical techniques for in-depth structural and functional characterization of gene therapy products in support of drug development, from pre-candidate selection through commercialization.  Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions About Sanofi: We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives Main responsibilities:   Develop and implement advanced characterization strategies for gene therapy candidates, including viral vectors and nonviral particles  Utilize a robust and sensitive LC-MS platform to profile HCP clearance throughout purification process and quantitatively monitor impurities of concern to support CMC product development   Establish HCP impurity method detection limits and precision, and oversee transfer and comparability to automated sample preparation methods within facility  Utilize LC-MS proteomics platform in profiling differential protein expression in cell lysates to support Cell Culture Process Development   Develop LC-MS characterization methods of nonviral particles including RNA impurity determination and oligonucleotide mapping  Collaborate cross functionally and support process/formulation development through comprehensive LC-MS characterization (peptide mapping, HCP analysis, and oligonucleotide analysis)  Establish new end-to-end automated data workflows (e.g. from data upload and application specific data processing to reporting in ELN)  Author technical documentation including reports, protocols, and regulatory filings (IND/IMPD/BLA)  Contribute to scientific literature and present at internal and external conferences  About You: Education:  Ph.D. in Biochemistry or Chemistry-life science related field, OR  M.S. with 4+ years of industry experience  Experience & Technical Skills: Extensive LC-MS experience in protein characterization, identification and protein quantitation   Proficiency with Thermo and/or AbSciex instruments and at least one peptide mapping/proteomics software such as Spectronaut, Genedata Expressionist, Protein Metrics, Skyline, or Proteome Discoverer Demonstrated success implementing novel analytical technologies  Preferred Qualifications: Experience with automation and AI-driven analytical workflows is highly desirable. Professional Skills: Excellent organizational and problem-solving abilities  Strong interpersonal and communication skills  Ability to work collaboratively in cross-functional teams  Why Choose Us: Bring the miracles of science to life alongside a supportive, future focused team. Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally. Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact. Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs. Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science. Help improve the lives of millions of people globally by making drug development quicker and more effective. Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. #GD-SG #LI-GZ #vhd #LI-Onsite Pursue progress , discover extraordinary Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to mak