Scientist / Sr. Scientist —Cell, Molecular & Chemical Biology (Taosheng Chen Lab)

At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children. The Taosheng Chen Lab within our  Department of Chemical Biology and Therapeutics is seeking a collaborative and innovative Scientist or Senior Scientist with expertise in cell biology, molecular biology, and/or chemical biology to lead research efforts to develop and characterize the mechanisms of action of novel chemical probes—including agonists, antagonists, and degraders—targeting the nuclear receptors PXR and CAR. The successful candidate will independently design and execute studies, generate high-quality datasets to test scientific hypotheses, and integrate findings across multiple disciplines. The candidate will work closely with in-house structural biologists and medicinal chemists to generate complementary data and advance projects, and will take a leading role in organizing and writing multidisciplinary manuscripts. The Chen Laboratory leverages multidisciplinary approaches to investigate the chemical regulation of nuclear receptors, with the overarching goal of elucidating nuclear receptor-driven transcriptional networks and developing innovative therapeutic strategies to combat drug resistance and tumorigenesis. Using integrated cellular, molecular, and chemical biology approaches, our research is closely aligned with structural biology and medicinal chemistry, enabling the successful execution of high-impact, collaborative studies. This synergistic framework has led to publications in leading journals, including Nature Communications (2017, 2024, 2025) and PNAS (2023), highlighting our contributions to advancing the understanding and therapeutic targeting of nuclear receptor signaling. The successful candidate will have a strong track record of high-quality research and publication in peer-reviewed journals. Relevant experience should include several of the following: DNA: cloning, plasmid construction, and related molecular biology techniques RNA: RNA isolation, gene expression analysis, and transcriptional profiling Proteins : Western blotting, protein–compound interactions, protein–protein interactions, and/or proteomic profiling Small molecules: experience evaluating the cellular activity, mechanism of action, and/or pharmacology of small-molecule compounds Structural biology: a basic understanding of protein crystal structures and ligand–protein interactions is essential for effective collaboration with structural biologists Medicinal chemistry: a basic understanding of small-molecule structures and structure–activity relationships is important for meaningful collaboration with medicinal chemists Murine studies experience is a plus Candidate Profile Priorities Our search will focus on candidates with: Strong cell and molecular biology expertise with exposure to chemical biology Experience evaluating small-molecule mechanisms of action An understanding of structural biology and medicinal chemistry concepts A demonstrated record of impactful publications, particularly in high-quality journals Academic and industry backgrounds will both be considered Research Focus & Key Projects The selected candidate will play a leading role in advancing the laboratory's efforts to understand and therapeutically target the nuclear receptors PXR and CAR through multidisciplinary approaches spanning cell biology, molecular biology, chemical biology, structural biology, and medicinal chemistry. Current projects include: Developing and characterizing novel chemical probes , including agonists, antagonists, and degraders, targeting nuclear receptors. Investigating the mechanisms of action of small molecules and protein degraders, including PROTAC-based approaches. Defining how chemical modulation of PXR and CAR influences transcriptional networks, drug metabolism, chemotherapy response, and tumorigenesis. Collaborating with structural biologists to understand ligand-protein interactions and guide structure-based discovery efforts. Leading the integration of multidisciplinary findings into manuscripts, publications, and future grant-supported research initiatives. Job Responsibilities: Conducts experiments/projects independently under overall direction of the PI and/or more senior scientist Develops new research protocols, techniques and procedures. Identifies experimental data pertinent to the analysis problem. Processes, organizes and summarizes data, reporting these experimental results. Monitors quality and integrity of recorded information and data. Ensures data collection and entry methods meet quality standards. Interprets data as it relates to research problem. May publish as co-author and/or draft sections of research manuscripts as necessary. Presents research to colleagues within the organization or at external meetings/events. Provides lab operation support and makes recommendations regarding equipment use and maintenance, supplies, etc. Troubleshoots instrument and equipment issues. Provides input into lab operation processes and procedures. Recommends equipment acquisition and decommissioning. Regularly trains and oversees the work of others in laboratory techniques and procedures. Performs other related duties as assigned in order to meet the goals of the department and institution. Maintains regular and predictable attendance Minimum Education: Bachelor's degree in relevant scientific area is required A PhD in cell biology, molecular biology, chemical biology, pharmacolo