Head of Global Manufacturing Science & Technology

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide. Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma. Legend Biotech is seeking a Head of Global Manufacturing Science & Technology as part of the Manufacturing Science & Technology team based in Bridgewater, NJ. Role Overview The  Head of Global Manufacturing Science & Technology (MSAT) is the enterprise technical leader responsible for ensuring the robustness, scalability, capability, and continuous improvement of manufacturing processes across the product lifecycle. The role establishes the global MSAT strategy and provides technical leadership from late-stage development and technology transfer through commercial manufacturing and lifecycle management. The Head of Global Manufacturing Science & Technology  ensures that manufacturing processes are scientifically understood, technically capable, operationally robust, scalable, and continuously improved to support reliable supply, product quality, patient needs, and business growth. As the enterprise technical authority for manufacturing processes, the Head of Global Manufacturing Science & Technology  drives process robustness, technology transfer, process validation, continued process verification, technical investigations, manufacturing optimization, and advanced manufacturing capabilities across the global network. The incumbent will be a member of the GMS Leadership Team. Key Responsibilities Global MSAT Strategy & Technical Leadership Define and execute the global MSAT strategy and operating model aligned with business, portfolio, and manufacturing priorities. Establish global technical standards, capabilities, and governance for manufacturing processes across internal and external sites. Serve as the senior technical authority for process capability, robustness, scalability, and manufacturing performance. Process Technology & Manufacturing Performance Own the technical strategy for process characterization, validation, process capability, continued process verification, and process monitoring. Drive consistency and systematic improvement of manufacturing processes to increase yield, reliability, capacity, throughput, consistency, and cost efficiency. Provide technical leadership for manufacturing investigations, process deviations, and recurring performance issues. Establish science- and data-based approaches to identify process risks and proactively improve manufacturing performance. Technology Transfer & Commercialization Provide MSAT leadership for technology transfer and manufacturing readiness from development into commercial operations. Ensure effective transfer of process knowledge, control strategies, technical standards, and manufacturing capabilities into internal and external manufacturing networks. Partner with CMC and R&D to ensure development programs are designed for commercial scalability, manufacturability, and process robustness. Provide technical input to major manufacturing network, capacity, and commercialization decisions. Lifecycle Management & Continuous Improvement Own the MSAT strategy for the technical lifecycle of commercial products, including process improvements, scale-up/scale-out, site transfers, capacity expansion, and manufacturing optimization. Identify and prioritize opportunities to improve quality, yield, throughput, cost, cycle time, and supply resilience. Lead implementation of advanced process technologies, automation, modeling, analytics, and digital manufacturing capabilities. Ensure manufacturing knowledge and process data are systematically leveraged to drive continuous improvement. Manufacturing & Global Network Provide technical leadership, support and governance for MSAT activities at internal sites, CMOs/CDMOs and other external manufacturing partners. Ensure consistent technical standards, process understanding, technology transfer, and lifecycle management across the global manufacturing network. Partner with Manufacturing leadership to resolve technical, process, and performance issues. Innovation, Digital & Advanced Manufacturing Establish the strategic roadmap for advanced manufacturing technologies, automation, digital manufacturing, process analytics, and data science. Accelerate adoption of emerging technologies that improve manufacturing control, predictability, flexibility, and efficiency. Promote the use of data-driven and predictive approaches to enhance process understanding and manufacturing performance. Executive Leadership & Organization Build and lead a high-performing global MSAT organization with the technical depth and capabilities required to support a growing pipeline and commercial portfolio. Develop organizational capabilities, talent, succession, and technical leadership across the global manufacturing network. Serve as a senior member of the Global Manufacturing & Supply Leadership Team, contributing to manufacturing strategy, investment decisions, portfolio p